How Is Your Medication Given?

What is the difference between Entyvio subcutaneous (SC) and Entyvio intravenous (IV) infusion?

It is the same medicine, with the same active ingredient. Both forms of Entyvio have been proven to help your gut feel better.1 The main difference between the two forms is the way the medicine gets into your body. Intravenous means it goes through a drip in one of the veins in your arm (intravenous infusion). Subcutaneous means it goes into tissue under the skin (subcutaneous injection).1,2

How will you be treated

Your first doses of Entyvio will be given as IV infusions before you move onto Entyvio SC.
Someone on your healthcare team will be in charge of your infusions.

Once you have had your induction doses of Entyvio IV, you will then be able to receive Entyvio SC. Either you or someone you choose will inject Entyvio SC at home.

How often will treatment be given?

Your treatment will begin with at least two starter doses of Entyvio, given as IV infusions before you can start injecting Entyvio SC at home. You will need to visit a hospital or clinic to receive your starter doses. Your healthcare team will give your medication through IV infusion. The infusion lasts for about 30 minutes each time. You will need to stay for a while after your infusion to be monitored in case there are any unusual signs of allergic or infusion reactions.

Your starter doses will be two weeks apart; however, you may need more than two infusions depending on how you respond to the medicine.

The recommended dose of Entyvio IV is 300 mg.

How Often Will Treatment Be Given?

The first injection under the skin is given at the time of the next scheduled intravenous infusion, and every 2 weeks thereafter.

If you have been receiving Entyvio IV for a while and the decision has been made by your healthcare professional to switch from Entyvio IV to Entyvio SC, you will not need to have the induction doses. Your healthcare professional will discuss your treatment with you.

Injecting Entyvio SC at home

You should have been shown how to use your Entyvio device by someone on your healthcare team and will have the option of injecting your medicine through a pen or syringe. Once your first Entyvio SC delivery arrives, your homecare nurse will be in contact to arrange training to show you how to self-inject.

It is important to note that the injection devices follow different processes to ensure that you inject your medicine correctly.

How to inject by pen and syringe

Download an electronic copy of the step-by-step guide to self-inject your dose of Entyvio SC by pen here or syringe here.

You might want to get someone you know and trust to help you – not just with the practicalities but for emotional support too. Before you inject, you and your chosen person will be provided training of how to inject safely by a homecare nurse. Your chosen person can also refer to the step-by-step guides and videos.

Entyvio SC Patient Frequently Asked Questions (FAQ) Booklet

You may have questions on how to store your medication at home, additional queries on how to self-inject or what to do if you are travelling; the Entyvio SC Patient FAQ Booklet provides further information on these topics and highlights who to contact for further advice. Download an electronic copy here.

Entyvio SC Patient Booklet

This patient booklet provides further information when preparing to inject, advice and support as well as quick tips. You may already have been given a printed copy of this informative booklet by your healthcare professional, but you can also view or Download an electronic copy here.

Entyvio SC Carer Booklet

This carer booklet provides further information, advice and tips for the person you chose to help you self-inject and to support them when preparing to inject. Download an electronic copy here.

Reporting of Side Effects

If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed on this website or in the Patient Information Leaflet. You can also report side effects directly via the Yellow Card Scheme at

By reporting side effects you can help provide more information on the safety of this medicine.